FAM133B

Across TCGA pan-cancer cohorts, FAM133B RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FAM133B data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher FAM133B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM133B expression acts as an unfavorable survival marker, although some lineages such as UCS and LAML show a favorable association.

KIRP, UCS, and KICH are the cancer types where FAM133B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	III,IV	0.192	0.688	.001	86	view →
UCS	OS	Tertile	II,III,IV	0.684	0.271	.005	70	view →
KICH	DFS	Median	II,III,IV	0.534	0.924	.001	65	view →
LAML	DFS	Tertile	All	0.479	0.216	.006	34	view →
UVM	DFS	Quartile	III,IV	0.183	0.832	<.001	32	view →
BRCA	DFS	Tertile	III,IV	0.598	0.425	.012	25	view →
ACC	DFS	Quartile	All	0.508	0.830	.006	21	view →
STAD	OS	Tertile	III,IV	0.744	0.560	.012	19	view →
LUSC	OS	Median	All	0.822	0.634	.007	18	view →
LGG	OS	Tertile	All	0.746	0.864	.003	16	view →
SCLC	OS	Tertile	All	0.422	1.000	.003	13	view →
CHOL	DFS	Tertile	All	0.563	0.215	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FAM133B–KIRP (OS)

Open the KIRP breakdown →