FAM133B

Across TCGA patient cohorts, FAM133B mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM133B-associated genes across cancer lineages are PANK4, ABHD3, and GOLGA6A. Each is linked with FAM133B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM133B-to-partner and partner-to-FAM133B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANK4 grouped by FAM133B-low versus FAM133B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133B→partner) and Y-score (partner→FAM133B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PANK4 →	+0.479	+3.274	.002	.008	3	1
UCEC	ABHD3 →	+0.707	+3.343	.006	.005	3	1
UCEC	GOLGA6A →	+0.029	+2.313	.005	.004	3	1
UCEC	FCRL3 →	+0.511	+3.595	<.001	.001	3	1
UCEC	FCRL4 →	+0.143	+2.436	<.001	.007	3	1
UCEC	CCDC51 →	+0.557	+3.475	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

PANK4 by FAM133B expression — UCEC

Explore this box plot interactively →