FAM133B

Across TCGA patient cohorts, FAM133B mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM133B-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and JNK2. Each is linked with FAM133B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM133B-to-partner and partner-to-FAM133B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FAM133B-low versus FAM133B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133B→partner) and Y-score (partner→FAM133B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.116	-2.986	.046	.037	3	1
UCEC	A-Raf_pS299 →	-0.153	-3.000	.026	.037	3	1
UCEC	JNK2 →	+0.309	+3.000	.007	.037	3	1
UCEC	JNK_pT183_Y185 →	-0.213	-2.986	.029	.037	1	1
UCEC	p21 →	+0.280	+3.000	.011	.037	1	1
UCEC	Annexin-1 →	+0.925	+3.000	.002	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

14-3-3_beta by FAM133B expression — UCEC

Explore this box plot interactively →