FAM133A

Across TCGA patient cohorts, FAM133A protein abundance is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FAM133A-associated genes across cancer lineages are CHD8, PXMP4, and SIGLEC6. Each is linked with FAM133A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM133A-to-partner and partner-to-FAM133A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM133A versus CHD8 in BRCA, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133A→partner) and Y-score (partner→FAM133A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHD8 →	-0.854	-0.771	<.001	.005	3	1
BRCA	PXMP4 →	-1.379	-0.929	<.001	<.001	3	1
BRCA	SIGLEC6 →	-0.944	-0.698	.007	.005	3	1
BRCA	PLGRKT →	-1.258	-0.920	.004	.001	3	1
BRCA	MPP2 →	-1.773	-0.739	.001	.002	3	1
BRCA	HMGXB3 →	-0.732	-0.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

FAM133A vs CHD8 — BRCA

Explore this scatter interactively →