FAM133A

Across TCGA pan-cancer cohorts, FAM133A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FAM133A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM133A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM133A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where FAM133A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM133A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.260	<.001	8	view →
KICH	Female	II,III,IV	−0.251	<.001	8	view →
LIHC	Male	All	+1.437	<.001	6	view →
COAD	All	All	−0.106	<.001	6	view →
KIRC	Female	All	−0.133	.001	5	view →
LUAD	All	All	+0.938	<.001	4	view →
LUSC	All	All	+0.523	.001	4	view →
KIRP	All	III,IV	+0.372	.032	4	view →
HNSC	All	All	+0.440	.021	2	view →
READ	Female	All	−0.306	.013	2	view →
UCEC	All	All	−0.304	.043	2	view →
BLCA	Male	IV	−0.190	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FAM133A–THCA

Open the THCA breakdown →