FAM133A

Across TCGA patient cohorts, FAM133A mutation is significantly associated with the RNA expression of many other genes, with 4,519 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM133A-associated genes across cancer lineages are RPL5P21, BUB3, and RNASEH1. Each is linked with FAM133A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM133A-to-partner and partner-to-FAM133A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL5P21 grouped by FAM133A-low versus FAM133A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133A→partner) and Y-score (partner→FAM133A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL5P21 →	+0.058	+4.505	<.001	.009	3	3
UCEC	BUB3 →	+0.585	+2.169	<.001	<.001	3	3
UCEC	RNASEH1 →	+0.421	+2.828	.001	.001	3	3
COAD	RNU1-52P →	+0.247	+4.239	<.001	.005	3	3
SKCM	ZNF101P1 →	+0.029	+3.065	<.001	.001	3	2
CESC	HMGN1P31 →	+0.070	+3.590	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,519 associations by consensus.

RPL5P21 by FAM133A expression — HNSC

Explore this box plot interactively →