FAM133A

Across TCGA patient cohorts, FAM133A mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM133A-associated genes across cancer lineages are TIGAR, ATM, and eEF2. Each is linked with FAM133A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM133A-to-partner and partner-to-FAM133A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by FAM133A-low versus FAM133A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133A→partner) and Y-score (partner→FAM133A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.153	+1.611	.002	.005	3	3
UCEC	ATM →	-0.609	-3.893	<.001	<.001	3	3
UCEC	eEF2 →	+0.330	+1.700	.005	.040	3	2
UCEC	A-Raf_pS299 →	-0.118	-2.000	.003	.009	3	2
UCEC	ERK2 →	+0.224	+1.847	<.001	.007	3	2
UCEC	GAPDH →	+0.417	+1.700	.020	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

TIGAR by FAM133A expression — UCEC

Explore this box plot interactively →