FAM133A

Across TCGA cell cohorts, FAM133A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,353 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FAM133A-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, Tie signaling pathway, and Positive regulation of keratinocyte differentiation. Each is linked with FAM133A in more than 6 cancer types. Because this analysis shows association rather than direction, both FAM133A-to-partner and partner-to-FAM133A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition grouped by FAM133A-low versus FAM133A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM133A→partner) and Y-score (partner→FAM133A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.079	+0.804	<.001	.004	3	7
BLOOD_Myeloma	Tie signaling pathway →	+0.984	+2.160	.004	<.001	3	7
BONE	Positive regulation of keratinocyte differentiation →	-0.213	-1.557	.001	.006	3	6
LUNG_NSCLC_LUAD	Positive regulation of telomere maintenance →	+0.046	+0.863	<.001	.005	3	6
STOMACH	Regulation of spindle checkpoint →	+0.060	+0.894	.004	.007	3	5
SKIN	IMP salvage →	+0.155	+1.287	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,353 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition by FAM133A expression — SKIN

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