FAM126B

Across TCGA pan-cancer cohorts, FAM126B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FAM126B data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM126B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM126B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and HNSC are the cancer types where FAM126B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.332	0.875	.016	16	view →
CCRCC	OS	Quartile	All	0.935	0.684	.009	13	view →
HNSC	DFS	Median	III,IV	0.880	0.657	.013	9	view →
UCEC	DFS	Median	All	0.924	0.785	.021	8	view →
PDAC	DFS	Quartile	III,IV	0.678	0.310	.016	7	view →
GBM	DFS	Quartile	All	0.785	0.583	.014	6	view →
LSCC	DFS	Median	III,IV	0.944	0.658	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FAM126B–LUAD (DFS)

Open the LUAD breakdown →