FAM126B

Across TCGA pan-cancer cohorts, FAM126B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FAM126B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM126B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM126B is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where FAM126B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM126B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.111	<.001	11	view →
THCA	Male	III,IV	−0.967	<.001	11	view →
KICH	Female	All	−0.986	<.001	8	view →
KIRC	Male	All	−0.329	.001	6	view →
READ	All	All	−0.864	<.001	5	view →
KIRP	Male	All	−0.515	<.001	5	view →
STAD	All	III,IV	+0.582	.022	3	view →
CHOL	All	All	+0.713	.002	2	view →
ESCA	Female	All	+1.053	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FAM126B–COAD

Open the COAD breakdown →