FAM126B

Across TCGA patient cohorts, FAM126B mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM126B-associated genes across cancer lineages are eIF4E, eEF2, and Shc_pY317. Each is linked with FAM126B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM126B-to-partner and partner-to-FAM126B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FAM126B-low versus FAM126B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM126B→partner) and Y-score (partner→FAM126B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.173	+3.335	.015	.005	3	3
UCEC	eEF2 →	+0.271	+1.874	.025	.049	3	2
UCEC	Shc_pY317 →	-0.214	-2.523	<.001	<.001	3	2
UCEC	C-Raf_pS338 →	-0.080	-1.247	.003	.045	3	2
UCEC	14-3-3_beta →	-0.129	-3.060	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.301	-2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

eIF4E by FAM126B expression — UCEC

Explore this box plot interactively →