FAM126A

Across TCGA patient cohorts, FAM126A mutation is significantly associated with the RNA expression of many other genes, with 800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM126A-associated genes across cancer lineages are HMGB3P20, MTCYBP10, and RNU6-458P. Each is linked with FAM126A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM126A-to-partner and partner-to-FAM126A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB3P20 grouped by FAM126A-low versus FAM126A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM126A→partner) and Y-score (partner→FAM126A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	HMGB3P20 →	+0.116	+2.925	.002	.002	3	2
BLCA	MTCYBP10 →	+0.083	+4.704	<.001	.005	3	2
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	2
SKCM	CCNJP1 →	+0.046	+5.362	<.001	.005	3	2
UCEC	TUBGCP5 →	+0.370	+2.135	.005	.002	3	2
BLCA	RNU6-591P →	+0.271	+5.033	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 800 associations by consensus.

HMGB3P20 by FAM126A expression — COAD

Explore this box plot interactively →