FAM122C

Across TCGA pan-cancer cohorts, FAM122C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM122C data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FAM122C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM122C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD and UCEC are the cancer types where FAM122C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.168	0.788	.005	12	view →
UCEC	DFS	Median	All	0.961	0.630	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM122C–COAD (OS)

Open the COAD breakdown →