FAM122B

Across TCGA patient cohorts, FAM122B mutation is significantly associated with the RNA expression of many other genes, with 2,341 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM122B-associated genes across cancer lineages are RNU6-781P, MIR6766, and H2AB2. Each is linked with FAM122B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM122B-to-partner and partner-to-FAM122B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-781P grouped by FAM122B-low versus FAM122B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM122B→partner) and Y-score (partner→FAM122B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-781P →	+0.287	+1.656	<.001	.007	3	2
BRCA	MIR6766 →	+0.735	+5.575	<.001	.004	3	1
BRCA	H2AB2 →	+0.083	+8.057	<.001	.005	3	1
BRCA	MIR6754 →	+0.785	+5.883	<.001	.003	3	1
CESC	RPL12P45 →	+0.158	+4.503	<.001	.005	3	1
CESC	ERICH3-AS1 →	+0.396	+4.816	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,341 associations by consensus.

RNU6-781P by FAM122B expression — UCEC

Explore this box plot interactively →