FAM120B

Across TCGA patient cohorts, FAM120B mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM120B-associated genes across cancer lineages are ATM, RAD51, and XBP1. Each is linked with FAM120B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM120B-to-partner and partner-to-FAM120B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM120B-low versus FAM120B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM120B→partner) and Y-score (partner→FAM120B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.619	-2.209	<.001	.009	3	3
COAD	RAD51 →	+0.177	+3.178	.022	.010	3	2
COAD	XBP1 →	+0.281	+3.178	.002	.010	3	2
UCEC	FoxM1 →	+0.220	+2.331	.011	.003	3	2
UCEC	MEK1 →	+0.473	+3.807	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.102	-1.321	.044	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by FAM120B expression — UCEC

Explore this box plot interactively →