FAM120B

Across TCGA pan-cancer cohorts, FAM120B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated FAM120B data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher FAM120B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM120B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

OV, KIRC, and SCLC are the cancer types where FAM120B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	III,IV	0.258	0.382	<.001	108	view →
KIRC	OS	Tertile	All	0.745	0.536	<.001	71	view →
SCLC	DFS	Tertile	II,III,IV	0.847	0.350	<.001	52	view →
LGG	DFS	Tertile	All	0.488	0.307	<.001	32	view →
PAAD	DFS	Quartile	All	0.435	0.158	.008	22	view →
BLCA	OS	Quartile	IV	0.280	0.668	.003	18	view →
KIRP	DFS	Quartile	III,IV	0.182	0.720	.009	16	view →
LUAD	DFS	Median	IV	0.351	0.640	.025	14	view →
HNSC	OS	Median	All	0.330	0.470	.012	14	view →
ACC	DFS	Tertile	All	0.468	0.845	.013	12	view →
READ	OS	Tertile	II,III,IV	0.944	0.493	.023	12	view →
PRAD	DFS	Quartile	All	0.963	0.887	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

FAM120B–OV (OS)

Open the OV breakdown →