FAM117A

Across TCGA patient cohorts, FAM117A mutation is significantly associated with the RNA expression of many other genes, with 590 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FAM117A-associated genes across cancer lineages are MIR6803, MIRLET7G, and BSNDP4. Each is linked with FAM117A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM117A-to-partner and partner-to-FAM117A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6803 grouped by FAM117A-low versus FAM117A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117A→partner) and Y-score (partner→FAM117A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6803 →	+0.121	+4.478	<.001	.003	3	3
SKCM	MIRLET7G →	+0.475	+3.238	<.001	.002	3	3
LUAD	BSNDP4 →	+0.243	+4.859	<.001	.004	3	2
LUAD	MIR8063 →	+0.701	+4.575	<.001	.001	3	2
UCEC	RNA5SP511 →	+0.188	+2.434	<.001	.009	3	2
UCEC	RN7SL454P →	+0.174	+2.186	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 590 associations by consensus.

MIR6803 by FAM117A expression — UCEC

Explore this box plot interactively →