FAM117A

Across TCGA pan-cancer cohorts, FAM117A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM117A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FAM117A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM117A is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where FAM117A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM117A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.522	<.001	11	view →
COAD	Male	All	−0.705	<.001	9	view →
KIRC	Male	II,III,IV	−0.576	<.001	9	view →
BLCA	Male	III,IV	−1.780	<.001	8	view →
THCA	Male	All	−0.819	<.001	8	view →
LUAD	All	II,III,IV	−0.607	<.001	7	view →
UCEC	All	All	−1.332	<.001	6	view →
BRCA	Female	All	−0.699	<.001	6	view →
READ	All	All	−1.118	.003	5	view →
KIRP	Male	All	−0.364	.004	4	view →
STAD	All	All	−0.717	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM117A–KICH

Open the KICH breakdown →