FAM117A

Across TCGA patient cohorts, FAM117A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM117A-associated genes across cancer lineages are FASN, eIF4E, and ACC1. Each is linked with FAM117A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM117A-to-partner and partner-to-FAM117A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by FAM117A-low versus FAM117A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117A→partner) and Y-score (partner→FAM117A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.585	+3.169	.002	.019	3	2
UCEC	eIF4E →	+0.222	+3.013	.029	.018	3	1
UCEC	ACC1 →	+0.426	+2.459	.015	.020	3	1
UCEC	MEK1 →	+0.421	+2.321	.017	.034	3	1
UCEC	MSH2 →	-0.271	-2.973	.014	.035	3	1
UCEC	p70-S6K →	+0.220	+2.486	.018	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

FASN by FAM117A expression — UCEC

Explore this box plot interactively →