FAM117A

Across TCGA cell cohorts, FAM117A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible FAM117A-associated genes across cancer lineages are KRTAP13-2, ARMH2, and KRT37. Each is linked with FAM117A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM117A-to-partner and partner-to-FAM117A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP13-2 grouped by FAM117A-low versus FAM117A-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM117A→partner) and Y-score (partner→FAM117A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	KRT37 →	+0.016	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	IFNA6 →	+0.120	+6.247	<.001	<.001	3	1
LARGE_INTESTINE	OR13D1 →	+0.034	+4.467	<.001	.004	3	1
LARGE_INTESTINE	TAFA1 →	+0.410	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KRTAP13-2 by FAM117A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →