FAM114A2

Across TCGA patient cohorts, FAM114A2 mutation is significantly associated with the RNA expression of many other genes, with 482 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM114A2-associated genes across cancer lineages are POLRMTP1, IGHV3-30, and VN1R88P. Each is linked with FAM114A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM114A2-to-partner and partner-to-FAM114A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLRMTP1 grouped by FAM114A2-low versus FAM114A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM114A2→partner) and Y-score (partner→FAM114A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLRMTP1 →	+0.396	+2.425	.006	.002	3	1
UCEC	IGHV3-30 →	+1.860	+2.415	.002	.003	3	1
SKCM	VN1R88P →	+0.073	+4.199	<.001	.009	3	1
HNSC	RNU6-706P →	+0.263	+7.954	<.001	.008	3	1
BRCA	TRDD1 →	+0.724	+7.473	<.001	.007	3	1
BRCA	NME2P3 →	+0.149	+4.220	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 482 associations by consensus.

POLRMTP1 by FAM114A2 expression — UCEC

Explore this box plot interactively →