FAM111A

Across TCGA patient cohorts, FAM111A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM111A-associated genes across cancer lineages are Caspase-7-cleavedD198, CDK1, and EGFR_pY1068. Each is linked with FAM111A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM111A-to-partner and partner-to-FAM111A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FAM111A-low versus FAM111A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111A→partner) and Y-score (partner→FAM111A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.473	+1.720	.021	.025	3	2
UCEC	CDK1 →	+0.112	+1.440	.032	.024	3	2
UCEC	EGFR_pY1068 →	-0.194	-1.736	.025	.007	3	1
UCEC	eIF4E →	+0.164	+3.472	.025	.002	3	1
UCEC	GAPDH →	+0.451	+2.700	.015	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.125	-1.700	.032	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by FAM111A expression — UCEC

Explore this box plot interactively →