FAM111A

Across TCGA pan-cancer cohorts, FAM111A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated FAM111A data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FAM111A RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM111A expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

BLCA, LGG, and MESO are the cancer types where FAM111A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.777	0.657	.004	60	view →
LGG	DFS	Median	All	0.596	0.872	<.001	54	view →
MESO	OS	Quartile	IV	0.151	0.666	.009	33	view →
HNSC	OS	Median	III,IV	0.167	0.459	.001	31	view →
KIRC	DFS	Tertile	II,III,IV	0.339	0.593	.012	31	view →
BRCA	OS	Quartile	All	0.979	0.946	.004	30	view →
SCLC	OS	Quartile	II,III,IV	0.241	0.982	.001	25	view →
ACC	DFS	Quartile	All	0.489	0.744	.015	24	view →
LIHC	OS	Median	All	0.707	0.850	.001	21	view →
SKCM	DFS	Tertile	All	0.224	0.156	.007	20	view →
READ	OS	Tertile	All	0.954	0.309	.007	18	view →
THYM	OS	Median	All	0.960	0.759	.004	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

FAM111A–BLCA (OS)

Open the BLCA breakdown →