FAM111A

Across TCGA cell cohorts, FAM111A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,304 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM111A-associated GO terms across cancer lineages are Negative regulation of cell cycle phase transition, Protein-DNA covalent cross-linking repair, and DNA-templated DNA replication maintenance of fidelity. Each is linked with FAM111A in more than 14 cancer types. Because this analysis shows association rather than direction, both FAM111A-to-partner and partner-to-FAM111A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle phase transition grouped by FAM111A-low versus FAM111A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111A→partner) and Y-score (partner→FAM111A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of cell cycle phase transition →	+0.059	+0.974	<.001	.002	3	15
UPPER_AERODIGESTIVE_TRACT	Protein-DNA covalent cross-linking repair →	+0.107	+1.223	<.001	<.001	3	14
BLOOD_Leukemia	DNA-templated DNA replication maintenance of fidelity →	+0.091	+1.204	<.001	<.001	3	14
BLOOD_Lymphoma	Positive regulation of chromosome organization →	+0.079	+1.364	<.001	<.001	3	12
OVARY	Negative regulation of mitotic cell cycle →	+0.043	+0.903	.002	.001	3	12
BLOOD_Leukemia	Centrosome duplication →	+0.083	+1.218	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,304 associations by consensus.

Negative regulation of cell cycle phase transition by FAM111A expression — OVARY

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