FAM111A

Across TCGA cell cohorts, FAM111A mutation is significantly associated with the RNA expression of many other genes, with 384 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM111A-associated genes across cancer lineages are SRY, ADPRM, and TIPIN. Each is linked with FAM111A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM111A-to-partner and partner-to-FAM111A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRY grouped by FAM111A-low versus FAM111A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM111A→partner) and Y-score (partner→FAM111A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SRY →	+0.062	+5.415	<.001	.004	3	2
LARGE_INTESTINE	ADPRM →	+0.549	+3.364	.006	.002	3	2
LARGE_INTESTINE	TIPIN →	+0.602	+3.364	.002	.002	3	2
BLOOD_Leukemia	PHOX2B →	+0.018	+3.102	<.001	.002	3	1
BLOOD_Leukemia	PTPN5 →	+0.393	+4.612	<.001	<.001	3	1
BLOOD_Leukemia	ZNF451 →	+0.793	+3.308	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 384 associations by consensus.

SRY by FAM111A expression — SKIN

Explore this box plot interactively →