FAM111A-DT

Across TCGA pan-cancer cohorts, FAM111A-DT RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of FAM111A-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM111A-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM111A-DT is over-expressed in tumor.

THCA, COAD, and HNSC are the cancer types where FAM111A-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM111A-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.247	<.001	10	view →
COAD	Male	All	+0.759	<.001	10	view →
HNSC	Male	III,IV	+0.752	<.001	10	view →
LIHC	Female	II,III,IV	+0.834	<.001	9	view →
BLCA	All	All	+0.815	<.001	9	view →
STAD	All	II,III,IV	+0.639	<.001	8	view →
KIRP	All	All	+0.364	.011	6	view →
BRCA	All	II,III,IV	+0.336	<.001	6	view →
KIRC	All	All	+0.293	<.001	5	view →
CHOL	Female	All	+2.539	<.001	3	view →
PRAD	All	All	+0.771	<.001	2	view →
READ	All	All	+0.567	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

FAM111A-DT–THCA

Open the THCA breakdown →