FAM107B

Across TCGA patient cohorts, FAM107B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM107B-associated genes across cancer lineages are Cyclin-B1, JNK2, and Ku80. Each is linked with FAM107B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM107B-to-partner and partner-to-FAM107B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FAM107B-low versus FAM107B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM107B→partner) and Y-score (partner→FAM107B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.540	+1.807	.019	.027	3	2
UCEC	JNK2 →	+0.297	+3.486	<.001	.002	3	1
UCEC	Ku80 →	+0.287	+2.594	.003	.006	3	1
UCEC	p62 Lck ligand →	+0.326	+3.321	.015	.009	3	1
UCEC	AMPK_pT172 →	+0.401	+1.820	.018	.016	3	1
UCEC	TFRC →	+0.509	+3.169	.020	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Cyclin-B1 by FAM107B expression — UCEC

Explore this box plot interactively →