FAM107B

Across TCGA pan-cancer cohorts, FAM107B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM107B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FAM107B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM107B is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and KIRP are the cancer types where FAM107B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM107B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.611	<.001	11	view →
KICH	All	III,IV	−1.857	<.001	10	view →
KIRP	Male	All	−0.919	<.001	8	view →
KIRC	Male	III,IV	−0.615	<.001	8	view →
LUSC	Female	II,III,IV	−1.592	<.001	7	view →
THCA	Female	All	−0.972	<.001	6	view →
STAD	All	All	+0.687	.002	3	view →
READ	All	All	−1.096	.004	2	view →
CHOL	All	All	+0.771	.003	2	view →
BLCA	All	IV	+1.100	.035	1	view →
LUAD	Female	II,III,IV	−0.300	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM107B–COAD

Open the COAD breakdown →