FAM106A

Across TCGA patient cohorts, FAM106A mutation is significantly associated with the RNA expression of many other genes, with 1,679 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM106A-associated genes across cancer lineages are SERF1AP1, COX15, and FADS1. Each is linked with FAM106A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM106A-to-partner and partner-to-FAM106A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERF1AP1 grouped by FAM106A-low versus FAM106A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM106A→partner) and Y-score (partner→FAM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SERF1AP1 →	+0.149	+2.694	<.001	.004	3	2
UCEC	COX15 →	+0.536	+3.708	<.001	<.001	3	1
UCEC	FADS1 →	+0.921	+2.502	<.001	.002	3	1
UCEC	EI24 →	+0.509	+2.502	.001	.002	3	1
UCEC	CHEK1 →	+0.751	+2.721	<.001	.003	3	1
UCEC	DLAT →	+0.759	+2.939	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,679 associations by consensus.

SERF1AP1 by FAM106A expression — UCEC

Explore this box plot interactively →