FAM106A

Across TCGA pan-cancer cohorts, FAM106A RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated FAM106A data layer compared with 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FAM106A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM106A expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

UCEC, OV, and LUSC are the cancer types where FAM106A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	II,III,IV	0.479	0.808	<.001	90	view →
OV	DFS	Quartile	All	0.475	0.599	.002	52	view →
LUSC	OS	Quartile	II,III,IV	0.277	0.597	<.001	48	view →
BLCA	DFS	Quartile	III,IV	0.324	0.571	.001	39	view →
UVM	DFS	Tertile	III,IV	0.095	0.706	.004	37	view →
ACC	OS	Tertile	IV	0.772	0.389	.001	37	view →
KICH	DFS	Median	III,IV	0.279	0.911	<.001	32	view →
LUAD	OS	Quartile	III,IV	0.482	0.812	.012	25	view →
PCPG	DFS	Median	All	0.876	0.960	.023	16	view →
KIRC	DFS	Quartile	IV	0.392	0.810	.002	12	view →
UCS	DFS	Quartile	II,III,IV	0.523	0.093	.024	12	view →
ESCA	OS	Quartile	III,IV	0.725	0.347	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

FAM106A–UCEC (OS)

Open the UCEC breakdown →