FAM106A

Across TCGA patient cohorts, FAM106A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM106A-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with FAM106A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM106A-to-partner and partner-to-FAM106A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by FAM106A-low versus FAM106A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM106A→partner) and Y-score (partner→FAM106A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.122	-2.973	.005	.035	3	1
UCEC	eEF2 →	+0.510	+2.115	.001	.019	3	1
UCEC	EGFR_pY1068 →	-0.313	-2.115	.004	.019	3	1
UCEC	FoxM1 →	+0.226	+2.115	.045	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.216	-3.690	<.001	.001	3	1
UCEC	GAPDH →	+0.542	+3.169	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

14-3-3_beta by FAM106A expression — UCEC

Explore this box plot interactively →