FAM104B

Across TCGA patient cohorts, FAM104B mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM104B-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and PKC-a. Each is linked with FAM104B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM104B-to-partner and partner-to-FAM104B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by FAM104B-low versus FAM104B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM104B→partner) and Y-score (partner→FAM104B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+1.050	+3.000	.011	.037	3	1
UCEC	Akt_pT308 →	+0.768	+3.000	.034	.037	3	1
UCEC	PKC-a →	-0.489	-3.000	.037	.037	3	1
UCEC	PTEN →	-0.616	-3.000	.007	.037	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Akt_pS473 by FAM104B expression — UCEC

Explore this box plot interactively →