FAM104B

Across TCGA pan-cancer cohorts, FAM104B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM104B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FAM104B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM104B is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where FAM104B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM104B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.034	<.001	11	view →
THCA	Male	IV	−1.229	<.001	11	view →
KIRC	Male	All	−0.471	<.001	11	view →
LIHC	Male	II,III,IV	+0.839	<.001	9	view →
LUAD	All	II,III,IV	−0.462	<.001	7	view →
UCEC	All	All	−0.653	<.001	6	view →
KIRP	All	All	−0.383	<.001	6	view →
CHOL	Male	All	+1.218	<.001	5	view →
BRCA	All	II,III,IV	+0.142	.026	5	view →
LUSC	Male	III,IV	−0.609	.019	2	view →
BLCA	Female	III,IV	+0.669	.025	1	view →
BLCA	Male	IV	−0.642	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

FAM104B–KICH

Open the KICH breakdown →