FAM102A

Across TCGA pan-cancer cohorts, FAM102A RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FAM102A data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM102A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM102A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, ACC, and COAD are the cancer types where FAM102A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.698	0.520	.001	59	view →
ACC	OS	Tertile	II,III,IV	0.735	0.943	.004	34	view →
COAD	OS	Quartile	II,III,IV	0.775	0.907	.009	29	view →
OV	OS	Quartile	All	0.281	0.402	.016	28	view →
CESC	OS	Median	All	0.911	0.833	.011	26	view →
PRAD	DFS	Quartile	All	0.890	0.963	.006	16	view →
KICH	OS	Quartile	II,III,IV	0.924	0.546	.030	10	view →
CHOL	DFS	Quartile	II,III,IV	0.651	0.141	.031	8	view →
SARC	OS	Quartile	All	0.850	0.628	.015	8	view →
LUSC	OS	Tertile	III,IV	0.238	0.503	.022	8	view →
LUAD	OS	Tertile	All	0.729	0.846	.037	7	view →
ESCA	OS	Tertile	IV	0.406	0.916	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FAM102A–HNSC (DFS)

Open the HNSC breakdown →