Across TCGA patient cohorts, FADS3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADS3-associated genes across cancer lineages are 4E-BP1, Collagen-VI, and Rb. Each is linked with FADS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FADS3-to-partner and partner-to-FADS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS3→partner) and Y-score (partner→FADS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	4E-BP1 →	+0.481	+3.459	.001	.005	3	2
SKCM	Collagen-VI →	-0.347	-3.459	.042	.005	3	2
UCEC	Rb →	+0.198	+3.019	.043	.019	3	1
UCEC	TFRC →	+0.804	+3.169	.005	.020	3	1
UCEC	c-Met_pY1235 →	+0.083	+2.817	.042	.036	3	1
SKCM	eEF2 →	+0.369	+2.321	.025	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

FADS3 survival (RNA) · tumor vs normal (RNA) · all FADS3 data types