Across TCGA pan-cancer cohorts, FADS3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FADS3’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FADS3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FADS3 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
HNSC, KIRC, and COAD are the cancer types where FADS3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FADS3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.