Across TCGA cell cohorts, FADS3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FADS3-associated genes across cancer lineages are ZNRF4, FMO1, and COX6A2. Each is linked with FADS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FADS3-to-partner and partner-to-FADS3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS3→partner) and Y-score (partner→FADS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNRF4 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	FMO1 →	+0.116	+3.777	.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR10C1 →	+0.020	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	PAPOLB →	+0.015	+4.196	<.001	.002	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.006	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

FADS3 survival (RNA) · tumor vs normal (RNA) · all FADS3 data types