FADS2B

Across TCGA pan-cancer cohorts, FADS2B RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of FADS2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FADS2B RNA is repressed in tumor relative to normal tissue. In most cancer types FADS2B is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, HNSC, and BRCA are the cancer types where FADS2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FADS2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.167	<.001	10	view →
HNSC	All	All	+0.184	<.001	9	view →
BRCA	All	II,III,IV	+0.036	.034	4	view →
LUAD	Female	II,III,IV	−0.068	.006	2	view →
STAD	Male	All	+0.056	.024	2	view →
KIRC	Male	All	−0.011	.015	2	view →
LIHC	Male	All	−0.010	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

FADS2B–COAD

Open the COAD breakdown →