FADS2

Across TCGA patient cohorts, FADS2 mutation is significantly associated with the RNA expression of many other genes, with 1,499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FADS2-associated genes across cancer lineages are RNU6-1207P, RNU6-376P, and FCGR1A. Each is linked with FADS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FADS2-to-partner and partner-to-FADS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1207P grouped by FADS2-low versus FADS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FADS2→partner) and Y-score (partner→FADS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1207P →	+0.426	+2.644	<.001	.008	3	3
SKCM	RNU6-376P →	+0.194	+4.302	<.001	.007	3	2
UCEC	FCGR1A →	+0.822	+3.483	<.001	.002	3	2
UCEC	BAG3 →	+0.630	+2.807	.003	.003	3	2
UCEC	AP1S3 →	+0.642	+2.860	.001	.001	3	2
UCEC	PELO →	+0.522	+3.213	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,499 associations by consensus.

RNU6-1207P by FADS2 expression — COAD

Explore this box plot interactively →