FABP4

Across TCGA pan-cancer cohorts, FABP4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FABP4 data layer compared with 4 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FABP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FABP4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCEC show a favorable association.

HNSC, ACC, and KIRC are the cancer types where FABP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.693	0.801	.002	77	view →
ACC	OS	Tertile	II,III,IV	0.663	1.000	<.001	42	view →
KIRC	DFS	Quartile	All	0.868	0.734	<.001	40	view →
BLCA	OS	Quartile	IV	0.179	0.519	<.001	37	view →
UCEC	DFS	Quartile	II,III,IV	0.897	0.707	.001	34	view →
LIHC	OS	Median	III,IV	0.648	0.405	.004	34	view →
ESCA	OS	Tertile	III,IV	0.689	0.402	.001	32	view →
LUAD	DFS	Tertile	IV	0.401	0.876	.005	26	view →
BRCA	OS	Tertile	III,IV	0.593	0.394	<.001	22	view →
LGG	OS	Tertile	All	0.837	0.739	.008	16	view →
OV	DFS	Median	All	0.501	0.580	.014	16	view →
THCA	DFS	Tertile	All	0.948	0.876	.021	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

FABP4–HNSC (OS)

Open the HNSC breakdown →