FABP4

Across TCGA pan-cancer cohorts, FABP4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FABP4 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher FABP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FABP4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LSCC, CCRCC, and COAD are the cancer types where FABP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.491	0.918	<.001	46	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	10	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
HNSC	DFS	Tertile	All	1.000	0.623	.040	6	view →
LUAD	OS	Quartile	II,III,IV	0.368	0.866	.017	5	view →
PDAC	OS	Median	II,III,IV	0.727	0.926	.012	3	view →
UCEC	OS	Median	All	0.959	0.866	.044	2	view →
GBM	OS	Quartile	All	0.744	1.000	.009	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FABP4–LSCC (DFS)

Open the LSCC breakdown →