FA2H

Across TCGA pan-cancer cohorts, FA2H mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FA2H’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where FA2H mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FA2H is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where FA2H tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FA2H mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.383	<.001	7	view →
LUAD	Male	III,IV	+0.322	.002	6	view →
PDAC	All	All	+0.925	.006	5	view →
LSCC	Male	All	−0.392	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FA2H–COAD

Open the COAD breakdown →