Across TCGA cell cohorts, F8 mutation is significantly associated with the RNA expression of many other genes, with 1,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible F8-associated genes across cancer lineages are ESR2, KMT5A, and TRIM49D2. Each is linked with F8 in more than 2 cancer types. Because this analysis shows association rather than direction, both F8-to-partner and partner-to-F8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F8→partner) and Y-score (partner→F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ESR2 →	+0.222	+1.936	.008	.005	3	3
LARGE_INTESTINE	KMT5A →	+0.617	+2.000	.002	.009	3	3
BLOOD_Myeloma	TRIM49D2 →	+0.056	+4.807	<.001	.006	3	2
LUNG_NSCLC_LUAD	MT1HL1 →	+0.065	+3.681	<.001	.009	3	2
BLOOD_Leukemia	VCY →	+0.590	+2.234	.005	.005	3	2
LARGE_INTESTINE	MTNR1A →	+0.430	+2.196	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,112 associations by consensus.

Exploration

F8 survival (RNA) · tumor vs normal (RNA) · all F8 data types