F2RL3

Across TCGA cell cohorts, F2RL3 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible F2RL3-associated genes across cancer lineages are OR4F21, NKX2-6, and C3orf85. Each is linked with F2RL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both F2RL3-to-partner and partner-to-F2RL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F21 grouped by F2RL3-low versus F2RL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2RL3→partner) and Y-score (partner→F2RL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F21 →	+0.151	+3.141	<.001	.002	3	2
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	C3orf85 →	+0.059	+5.539	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
SKIN	GALNTL5 →	+0.029	+4.415	<.001	.007	3	1
CNS	OR2D3 →	+0.042	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR4F21 by F2RL3 expression — LARGE_INTESTINE

Explore this box plot interactively →