F2RL3

Across TCGA pan-cancer cohorts, F2RL3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of F2RL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where F2RL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types F2RL3 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where F2RL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F2RL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.370	<.001	11	view →
HNSC	Female	IV	+2.156	<.001	11	view →
LIHC	Female	II,III,IV	+1.465	<.001	9	view →
LUSC	All	II,III,IV	−1.960	<.001	8	view →
LUAD	Male	All	−1.293	<.001	7	view →
KIRP	Male	All	−1.261	<.001	6	view →
STAD	Male	III,IV	+1.083	.001	6	view →
BRCA	Female	All	+0.520	<.001	4	view →
CHOL	All	All	+1.932	<.001	3	view →
UCEC	All	IV	+1.755	.040	2	view →
READ	Male	All	+1.420	.044	2	view →
KICH	Female	III,IV	−1.546	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

F2RL3–KIRC

Open the KIRC breakdown →