F2RL1

Across TCGA pan-cancer cohorts, F2RL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated F2RL1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher F2RL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated F2RL1 expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM, CCRCC, and PDAC are the cancer types where F2RL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.648	0.390	.028	12	view →
CCRCC	OS	Tertile	II,III,IV	0.993	0.654	.020	4	view →
PDAC	DFS	Quartile	All	0.209	0.830	.024	3	view →
LSCC	DFS	Tertile	II,III,IV	0.937	0.555	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

F2RL1–GBM (OS)

Open the GBM breakdown →