F2RL1

Across TCGA pan-cancer cohorts, F2RL1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of F2RL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where F2RL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types F2RL1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, KICH, and COAD are the cancer types where F2RL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F2RL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.415	<.001	12	view →
KICH	Female	II,III,IV	−4.037	<.001	11	view →
COAD	Female	IV	−1.424	<.001	11	view →
LUAD	Male	II,III,IV	+1.525	<.001	8	view →
READ	All	All	−1.688	<.001	7	view →
KIRC	All	II,III,IV	−0.581	.003	6	view →
LUSC	Male	All	+1.437	<.001	5	view →
STAD	All	All	+1.189	.027	4	view →
KIRP	All	IV	+1.075	.022	4	view →
CHOL	Male	All	+2.245	<.001	2	view →
UCEC	All	All	+1.849	.001	2	view →
PRAD	All	All	+0.661	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

F2RL1–HNSC

Open the HNSC breakdown →