F2RL1

Across TCGA patient cohorts, F2RL1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible F2RL1-associated genes across cancer lineages are MEK1, IRS1, and MSH2. Each is linked with F2RL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both F2RL1-to-partner and partner-to-F2RL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by F2RL1-low versus F2RL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (F2RL1→partner) and Y-score (partner→F2RL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.491	+3.807	.002	<.001	3	2
SKCM	IRS1 →	+0.245	+2.321	.001	.035	3	1
UCEC	MSH2 →	-0.213	-2.973	.040	.035	3	1
UCEC	mTOR_pS2448 →	-0.145	-2.565	.031	.010	3	1
UCEC	Notch1 →	+0.249	+3.335	<.001	.005	3	1
UCEC	p21 →	+0.215	+3.013	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MEK1 by F2RL1 expression — UCEC

Explore this box plot interactively →