F2R

Across TCGA pan-cancer cohorts, F2R mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated F2R data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher F2R mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated F2R expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where F2R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.340	0.951	.002	22	view →
LSCC	OS	Median	All	0.922	0.836	.034	3	view →
LUAD	OS	Median	All	1.000	0.902	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

F2R–PDAC (DFS)

Open the PDAC breakdown →