F2R

Across TCGA pan-cancer cohorts, F2R RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of F2R’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where F2R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types F2R is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where F2R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in F2R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.611	<.001	12	view →
KIRC	Female	All	+1.226	<.001	11	view →
COAD	Male	III,IV	+1.563	<.001	10	view →
BLCA	All	III,IV	+1.068	.001	10	view →
STAD	Male	II,III,IV	+2.098	<.001	9	view →
KICH	Male	II,III,IV	−2.000	<.001	8	view →
THCA	Male	All	+1.262	<.001	7	view →
BRCA	All	III,IV	+1.269	<.001	6	view →
CHOL	All	All	+1.762	<.001	3	view →
ESCA	All	All	+2.015	.002	2	view →
KIRP	Male	All	−1.139	<.001	2	view →
LUAD	Female	II,III,IV	−0.737	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

F2R–HNSC

Open the HNSC breakdown →